Olpaza 150mg Tablet Abu Dhabi | Top Pharma Exporter from India

Olpaza 150mg Tablet: Advanced PARP Inhibitor for Targeted Oncology Care

Are you looking for a reliable Olpaza 150 mg tablet exporter from India? Ernest Oncology, a premier division of Ernest Pharmaceutical Pvt. Ltd., is a leading global supplier and bulk distributor of specialized targeted therapies. We provide a robust, regulatory-compliant supply chain to the UK (London), USA, UAE (Abu Dhabi), Australia, and South Africa, ensuring that high-intensity oncology medications reach healthcare providers with pharmaceutical-grade integrity.

Detailed Product Overview: What is Olpaza 150mg?

Olpaza 150 mg is an oral targeted therapy containing the active pharmaceutical ingredient Olaparib. It belongs to a revolutionary class of medications known as Poly (ADP-ribose) Polymerase (PARP) Inhibitors. Olpaza is specifically designed to treat cancers associated with defects in DNA repair mechanisms, particularly those involving the BRCA1 and BRCA2 gene mutations.

The 150mg tablet is the standard therapeutic strength used in modern clinical protocols to provide maintenance therapy, helping to delay the progression of cancer and extend the interval between chemotherapy treatments.

Primary Therapeutic Indications:

Olpaza 150 mg is clinically indicated for several high-need oncological conditions:

• Advanced Ovarian Cancer: As a first-line maintenance treatment for adult patients with BRCA-mutated advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in response to platinum-based chemotherapy.

• HER2-Negative Metastatic Breast Cancer: For patients with germline BRCA-mutated (gBRCAm) metastatic breast cancer who have been previously treated with chemotherapy.

• Metastatic Pancreatic Cancer: As maintenance treatment for adult patients with gBRCAm metastatic pancreatic adenocarcinoma.

• Prostate Cancer (mCRPC): For patients with specific DNA repair gene mutations (HRR gene-mutated) who have progressed following prior treatment with new hormonal agents.

Mechanism of Action: The Concept of Synthetic Lethality:

Olpaza 150 mg operates through a sophisticated biological principle called Synthetic Lethality:

1. Inhibition of PARP Enzymes: PARP enzymes are essential for repairing single-strand breaks in DNA. Olpaza binds to these enzymes, preventing the repair process.

2. DNA Damage Accumulation: In normal cells, double-strand breaks are repaired via "Homologous Recombination."

3. Exploiting BRCA Mutations: In cancer cells with BRCA1/2 mutations, this repair pathway is already broken. When Olpaza blocks the secondary repair pathway (PARP), the cancer cell accumulates so much DNA damage that it cannot survive.

4. Selective Destruction: Because healthy cells still have functional repair pathways, they are largely spared, while the BRCA-deficient cancer cells undergo apoptosis (programmed cell death).

Administration and Dosage: 

• Route: Oral (Tablets).

• Standard Dose: The typical recommended dose is 300 mg (two 150 mg tablets) taken twice daily.

• Usage: Can be taken with or without food. Tablets must be swallowed whole; do not chew, crush, or dissolve them.

• Duration: Treatment continues until disease progression or unacceptable toxicity.

Safety Profile & Monitoring: 

Clinicians must monitor patients for the following:

• Hematological Monitoring: Regular blood counts are necessary to check for anemia, neutropenia, or thrombocytopenia.

• MDS/AML: In rare cases, PARP inhibitors are associated with secondary bone marrow disorders; long-term monitoring is advised.

• Common Side Effects: Nausea, fatigue, vomiting, diarrhea, and decreased appetite.

Why Source Olpaza 150 mg from Ernest Oncology?

• Verified Exporter from India: Direct procurement from GMP-certified facilities, ensuring 100% authenticity and competitive B2B pricing.

• Global Logistics Expertise: Specialized in international shipping to the USA, UK, UAE, Australia, and South Africa , with full documentation and customs support.

• Bulk Supply Stability: Consistent inventory levels to support large-scale hospital supplies and international pharmacy distributors.

• Quality Assurance: Every shipment is handled with strict temperature controls to maintain the efficacy of the medication.