🔬 1. Product Overview: Azalieva 100mg Injection

Azalieva 100mg Injection is a life-saving chemotherapy medication containing Azacitidine, utilized primarily for treating high-risk blood and bone marrow disorders.

• Composition: Azacitidine (100mg per vial).

• Drug Class: Antimetabolite / Nucleoside metabolic inhibitor.

• Dosage Form: Sterile lyophilized powder for reconstitution (Injection).

• Storage Requirements: Must be stored in a refrigerator ($2^\circ\text{C}$ to $8^\circ\text{C}$) to maintain potency.

⚙️ 2. Mechanism of Action

Azalieva targets malignant cells through two primary pathways to restore normal blood cell production:

• Hypomethylation of DNA: It works by inhibiting DNA methyltransferase, which "turns back on" tumor suppressor genes that the cancer had silenced, allowing cells to mature and function normally.

• Cytotoxicity: By incorporating into the genetic material (DNA and RNA) of rapidly dividing cancer cells, it interferes with their growth and triggers cell death.

🏥 3. Clinical Indications & Uses

Azalieva 100mg Injection is the standard treatment for several complex hematological conditions:

• Myelodysplastic Syndromes (MDS): Indicated for all subtypes of MDS, where bone marrow fails to produce healthy blood cells.

• Acute Myeloid Leukemia (AML): Used for adult patients who are not candidates for aggressive stem cell transplants.

• Chronic Myelomonocytic Leukemia (CMML): Effective in treating this rare type of blood cancer.