Mabtas 100mg Rituximab Price USA | Ernest Oncology Indian Exporter

Mabtas 100mg Injection: Precision CD20-Targeted Immunotherapy for Oncology & Autoimmune Care

Are you looking for a trusted Mabtas 100 mg injection exporter from India? Ernest Oncology, a specialized division of Ernest Pharmaceutical Pvt. Ltd., is a premier global supplier and bulk distributor of advanced monoclonal antibodies. We provide a regulatory-compliant, cold-chain-integrated supply chain serving the USA, UK, Australia, and South Africa, ensuring that critical Rituximab therapies reach healthcare institutions with pharmaceutical-grade integrity and efficient global logistics.

Detailed Product Overview: What is Mabtas 100mg?

Mabtas 100 mg Injection is a chimeric monoclonal antibody containing the active ingredient Rituximab. Manufactured by Intas Pharmaceuticals Ltd., Mabtas is a high-quality biosimilar designed to provide the same clinical efficacy and safety profile as the reference product (Rituxan/MabThera).

For international B2B procurement, Mabtas 100mg (supplied as a 100mg/10ml concentrate in a single-dose vial) is a cornerstone treatment for various B-cell malignancies and severe autoimmune disorders.

Primary Therapeutic Indications

Mabtas 100 mg is clinically utilized globally for the following:

1. Non-Hodgkin Lymphoma (NHL): Specifically for Follicular Lymphoma and Diffuse Large B-Cell Lymphoma (DLBCL).

2. Chronic Lymphocytic Leukemia (CLL): Often used in combination with chemotherapy for superior patient outcomes.

3. Rheumatoid Arthritis (RA): For adult patients who have not responded adequately to TNF-antagonist therapies.

4. Granulomatosis with Polyangiitis (GPA) & Microscopic Polyangiitis (MPA): Managing severe vascular inflammation (Vasculitis).

5. Pemphigus Vulgaris (PV): A rare autoimmune condition causing severe skin and mucosal blistering.

Mechanism of Action: The Science of B-Cell Depletion

Mabtas works through a sophisticated immunological process known as Targeted CD20 Inhibition:

• CD20 Antigen Targeting: The antibody binds specifically to the CD20 antigen, a protein found on the surface of both healthy and malignant B-lymphocytes.

• Immune Recruitment: Once bound, Mabtas recruits the body's natural defenses to eliminate the target cells through:

  • Antibody-Dependent Cellular Cytotoxicity (ADCC): Recruiting NK cells to lyse the B-cells.

  • Complement-Dependent Cytotoxicity (CDC): Activating the complement system to destroy cell membranes.

  • Apoptosis: Signaling the cells to undergo programmed self-destruction.

• Rapid Depletion: This leads to a rapid reduction in circulating B-cells, which helps stop cancer progression and reduces the auto-antibody production causing inflammation in autoimmune diseases.

Administration and Clinical Safety

• Infusion Protocol: Mabtas must be administered as an intravenous (IV) infusion by a healthcare professional. It is not for IV bolus or push.

• Pre-medication: Standard clinical practice includes administering acetaminophen and an antihistamine to mitigate potential infusion-related reactions.

• Cold-Chain Management: Strict storage between 2°C to 8°C (36°F to 46°F) is mandatory. Do not freeze, shake, or expose to direct light.

• Key Monitoring:

• Hepatitis B Reactivation: Mandatory screening for HBV is required before the first dose.

• Infusion Reactions: Monitoring is most critical during the initial infusion.

• CBC Monitoring: Regular blood tests are essential to track white blood cell and platelet counts.

Why Source Mabtas from Ernest Oncology?

• Authentic Indian Exporter: Direct access to genuine Intas Pharmaceuticals inventory, providing 100% product authenticity and competitive wholesale pricing.

• Cold-Chain Authority: We utilize validated thermal packaging and real-time monitoring to ensure Rituximab remains within the required temperature range during transit to the USA, UK, Australia, and South Africa.

• Regulatory Compliance: We provide all essential B2B documentation, including GMP compliance, batch-specific COAs, and necessary export permits.

• Bulk Supply Stability: We specialize in large-scale orders for hospital groups, government tenders, and regional oncology distributors.