Piclib 100mg Palbociclib Price USA | Ernest Oncology Indian Exporter

Piclib 100mg Capsule: Precision CDK4/6 Inhibition for Advanced Breast Cancer

Are you seeking a trusted Piclib 100 mg capsule exporter from India? Ernest Oncology, a specialized division of Ernest Pharmaceutical Pvt. Ltd., is a premier global supplier and bulk distributor of advanced oncology treatments. We maintain a high-authority, regulatory-compliant supply chain serving the USA, UK, Australia, and South Africa, ensuring that life-saving targeted therapies reach healthcare providers with pharmaceutical-grade integrity and efficient global logistics

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Detailed Product Overview: What is Piclib 100mg?

Piclib 100 mg contains the active pharmaceutical ingredient Palbociclib. It is a potent, selective inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6), which are critical drivers of the cell cycle in many cancers.

Manufactured by Hetero Healthcare, Piclib is an internationally recognized generic version of the brand Ibrance. For international B2B procurement, Piclib 100mg offers a clinically validated, cost-effective solution for treating specific types of advanced breast cancer, helping patients manage disease progression with a well-tolerated oral regimen.

Primary Therapeutic Indications

Piclib 100mg Capsule is clinically indicated for the treatment of:

1. HR+/HER2- Advanced Breast Cancer: For patients with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer that is locally advanced or metastatic.

2. Initial Endocrine-Based Therapy: In combination with an aromatase inhibitor (such as Letrozole) as initial endocrine-based therapy in postmenopausal women.

3. Post-Endocrine Progression: In combination with Fulvestrant in patients with disease progression following endocrine therapy.

Mechanism of Action: How Piclib Works

Piclib targets the "engine" of cancer cell division to slow down tumor growth:

• Inhibiting CDK4/6: In HR+ breast cancer, the CDK4 and CDK6 proteins are often overactive, pushing cells to divide too quickly.

• Cell Cycle Arrest: Piclib blocks these proteins, preventing the cell from moving from the G1 phase to the S phase (the DNA replication phase) of the cell cycle.

• Synergy with Endocrine Therapy: When combined with hormone therapies, Piclib provides a "double hit" to the cancer—blocking both the hormone signals and the cell cycle machinery, leading to significantly delayed tumor growth.

Administration and Safety Guidelines

• Dosage Schedule: The standard dose is one 100mg capsule taken orally once daily for 21 consecutive days, followed by 7 days off (a 28-day cycle).

• Take with Food: Piclib capsules must be taken with food to ensure consistent absorption and effectiveness.

• Key Precautions:

  • Neutropenia (Low White Blood Cells): The most common side effect; regular blood counts (CBC) are required before each cycle.

  • Infection Risk: Patients should report fever or chills immediately.

  • Avoid Grapefruit: Grapefruit and grapefruit juice can increase the drug level in the blood to dangerous levels.

  • Storage: Store at room temperature (below 30°C) in a cool, dry place.

Why Source Piclib 100 mg from Ernest Oncology?

• Authentic Indian Exporter: Direct access to genuine Hetero Healthcare inventory, ensuring 100% product integrity and competitive wholesale pricing.

• Expertise in Global Distribution: Proven track record in navigating the customs and regulatory requirements of the USA, UK, Australia, and South Africa.

• Integrity & Trust: As part of Ernest Pharmaceutical Pvt. Ltd., we uphold the highest standards of transparency and quality in pharmaceutical trade.

• Bulk Supply Stability: We specialize in large-volume fulfillment for oncology clinics, hospital groups, and regional distributors.