Global Exporter & Bulk Supplier of Aprelieva 150 mg Injection
🌍 Introduction
Are you seeking a premier, globally compliant exporter of Aprelieva 150 mg Injection? At Ernest Oncology (a flagship division of Ernest Pharmaceutical Pvt. Ltd.), we specialize in the secure, efficient, and high-standard distribution of critical oncology supportive care. We supply Fosaprepitant 150 mg injections to hospitals, specialized cancer centers, and pharmaceutical wholesalers across the USA, UK, Australia, and South Africa.
🔬 1. Product Overview: Aprelieva 150 mg Injection
Aprelieva 150 mg Injection contains Fosaprepitant, a high-potency prodrug of aprepitant used to prevent the debilitating side effects of cancer treatment.
Composition: Fosaprepitant 150 mg (as a sterile lyophilized powder)
Therapeutic Class: Neurokinin-1 (NK1) Receptor Antagonist / Antiemetic
Formulation Type: Single-dose vial for intravenous (IV) infusion
Storage: Store at room temperature ($20^\circ\text{C}$ to $25^\circ\text{C}$). Reconstituted solution should be used within 24 hours.
⚙️ 2. Mechanism of Action
Aprelieva acts through a targeted central nervous system pathway to improve patient quality of life:
NK1 Receptor Blockade: Fosaprepitant is rapidly converted into aprepitant in the body.
It selectively blocks the Neurokinin-1 (NK1) receptors in the brain’s vomiting center. Substance P Inhibition: By preventing Substance P (a natural chemical messenger) from binding to these receptors, the medication halts the signals that trigger the nausea and vomiting reflex.
Dual-Phase Control: Unlike traditional antiemetics, it effectively manages both acute (first 24 hours) and delayed (24 to 120 hours) phases of chemotherapy-induced distress.
🏥 3. Therapeutic Indications
Aprelieva 150 mg Injection is clinically indicated for:
CINV Prevention: Prevention of acute and delayed nausea and vomiting associated with highly emetogenic cancer chemotherapy (HEC) and moderately emetogenic chemotherapy (MEC).
Combination Therapy: Used as part of a triple-therapy regimen alongside a 5-HT3 antagonist (like ondansetron) and a corticosteroid (like dexamethasone).
PONV Prevention: Prevention of postoperative nausea and vomiting in high-risk patients undergoing major surgery.
⚠️ 4. Administration & Safety Guidelines
Professional Use Only: Must be administered only by a healthcare professional via Intravenous (IV) Infusion over 20 to 30 minutes.
Timing: For chemotherapy, it is typically given 30 minutes before the start of the anti-cancer treatment.
Drug Interactions: Fosaprepitant can interact with medications like Warfarin, Dexamethasone, and certain oral contraceptives. Patients should use non-hormonal backup birth control during and for 30 days after treatment.
Side Effects: Common reactions include fatigue, diarrhea, headache, hiccups, and decreased appetite.
Disclaimer: Aprelieva 150 mg Injection is a potent prescription supportive care medication.
It must only be administered by a qualified healthcare professional in a clinical setting. Ernest Oncology is a global exporter and bulk supplier; this content is intended for B2B informational purposes and does not replace professional medical advice.
📞 Contact Ernest Oncology — Medicine Exporter
(GROUP OF ERNEST PHARMACEUTICAL PVT. LTD.)
🌐 Websites:
✉️ Contact Channels:
📧 Email Inquiries: exports@ernestpharmaceuticals.com
📦 Business Type: Exporter | Bulk Supplier | Distributor
📲 Call / WhatsApp: +91 93599 02383
🔗 WhatsApp Direct Link: https://wa.me/919359902383
