Anastrozole is a type of hormonal medicine known as an aromatase inhibitor. It reduces the amount of estrogen produced by the body. Some types of breast cancer need oestrogen to live and grow. Reducing oestrogen levels may therefore help slow or prevent the growth of hormone-sensitive breast cancer cells. Anastrozole tablets in the UK are generally supplied in a strength of 1 mg. Arimidex is a well-known brand name, while generic anastrozole products may also be available. The exact product prescribed or dispensed can depend on clinical requirements and local availability.What is Anastrozole 1 mg used for?
* Treatment of hormone receptor-positive early breast cancer
* Treatment of hormone receptor-positive advanced breast cancer
* Treatment following surgery or another breast-cancer therapy
* Treatment after a prescribed course of tamoxifen
* Breast-cancer risk reduction for selected postmenopausal women considered at moderate or high risk
A qualified healthcare professional must determine whether anastrozole is suitable for a particular patient. It is not an appropriate treatment for every type of breast cancer.
How does Anastrozole work?
Anastrozole blocks an enzyme called aromatase. This enzyme helps the body produce oestrogen after menopause. By blocking aromatase, the medicine lowers oestrogen levels. This is why anastrozole is commonly described as hormone therapy for breast cancer, even though it does not contain hormones. The medicine starts reducing oestrogen relatively quickly, but its full clinical effect can take longer. Patients should continue treatment for the period recommended by their oncology specialist. What is the usual Anastrozole dosage?
The usual prescribed adult dose is one Anastrozole 1 mg tablet once a day . However, patients must always follow the instructions given by their doctor or pharmacist. General administration instructions include:
* Swallow it whole with water
* Take it with or without food
* Do not take more than the prescribed dose
* Do not stop treatment until you have talked to the cancer team.
Anastrozole is often used as a long-term treatment. Some patients may be advised to take it for several years, depending on their diagnosis and treatment plan.
What to do if I miss a dose?
If a patient forgets a dose, they should follow the instructions in the medicine’s patient information leaflet or contact their pharmacist. A double dose should not be used to make up for a forgotten tablet. If it is nearly time for the next scheduled dose, the missed dose will generally be skipped and the regular schedule continued.
Common Anastrozole side effects
* Hot flushes
* Headache
* Tiredness or weakness
* Difficulty sleeping
* Low mood
* Nausea
* Loss of appetite
* Joint stiffness or discomfort
* Muscle or bone pain
* Increased sweating
* Hair thinning
* Vaginal dryness
Some symptoms resemble those experienced during menopause because anastrozole reduces oestrogen levels. Patients should tell their doctor if a side effect is persistent, severe or interfering with everyday activities. A healthcare professional can evaluate the symptoms and suggest suitable treatment.
Can Anastrozole affect bone health?
Long-term use of an aromatase inhibitor may reduce bone mineral density and increase the risk of osteoporosis or fractures in some patients.
Before and during treatment, a doctor may recommend:
* Bone-density assessments
* Vitamin D or calcium checks
* Appropriate weight-bearing exercise
* Medicines to protect bone strength when clinically required
Patients with osteoporosis, previous fractures or other bone conditions should inform their specialist before starting treatment.
Who may be unable to take anastrozole?
Anastrozole may not be suitable for everyone. Before treatment, a person should talk to their doctor if they:
* Have not yet reached menopause
* Are pregnant or trying to become pregnant
* Are breastfeeding
* Have osteoporosis or fragile bones
* Have severe kidney or liver problems
* Have an allergy to anastrozole or another ingredient in the tablet
* Have been advised to avoid lactose
* Are using hormone replacement therapy
Anastrozole is not normally recommended for children or adolescents.
Can Anastrozole be taken with other medicines?
People who take prescription drugs, over-the-counter drugs, vitamins, or herbal supplements should tell their doctor or chemist about all of them.
Hormone replacement therapy and other oestrogen-containing products may interfere with the way anastrozole works. Certain menopause supplements may also be unsuitable. Patients should not start or discontinue another treatment without professional advice.
Anastrozole versus Tamoxifen
Both anastrozole and tamoxifen can be used as hormonal treatments for breast cancer, but they work differently. Tamoxifen blocks the effects of oestrogen on certain cells, while anastrozole reduces the production of oestrogen. The choice between Anastrozole and Tamoxifen depends on factors such as menopause status, cancer characteristics, medical history and previous treatment.
Patients should not change from one medicine to another unless instructed by their oncology specialist.
* Their breast-cancer or oncology team
* A GP
* An NHS hospital pharmacy
* A registered community pharmacy
* A properly regulated online pharmacy
Patients using an online service should check that the pharmacy is registered with the General Pharmaceutical Council. Websites offering prescription medicines without an appropriate assessment or valid prescription should be avoided.
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Frequently Asked Questions
1. Is Anastrozole a chemotherapy medicine?
No. Anastrozole is hormonal therapy, also known as endocrine therapy. It works by lowering the amount of oestrogen produced by the body.
2. Can I take Anastrozole with food?
Anastrozole can usually be taken with or without food. The tablet should be swallowed whole with water.
3. How long is Anastrozole taken for?
Treatment length varies. Some patients take anastrozole for several years. The prescribing specialist decides the appropriate duration based on the patient’s diagnosis and treatment plan.
4. Does Anastrozole cause joint pain?
Joint stiffness and discomfort are recognised side effects. Patients experiencing severe or persistent joint pain should speak to their doctor rather than stopping treatment independently.
5. Can Anastrozole cause osteoporosis?
Reduced oestrogen may affect bone strength. Doctors may monitor bone density and recommend measures to protect bone health during long-term treatment.
6. Where can I obtain Anastrozole in Manchester?
Patients with a valid prescription can discuss dispensing arrangements with their hospital team or a registered pharmacy. Availability of a particular manufacturer or brand should be confirmed directly with the dispensing pharmacy.